Amniotic Membrane Medical Uses


The placenta connects the developing fetus via the umbilical cord to the uterine wall. The amniotic membrane encloses the developing fetus. The amniotic membrane is derived from the inner and outer layers of the amniotic sac and is comprised of two distinct but conjoined membranes – amnion and chorion. The amnion faces the fetus and the chorion faces the uterus.


Human amniotic membrane has been used for various types of reconstructive surgical procedures since the early 1900s, and it is now also used to treat difficult-to-heal wounds and soft tissue injuries. The amniotic membrane is a semi-permeable protective barrier that supports the healing cascade.


Doctors can use amniotic membrane to treat difficult-to-heal wounds, such as diabetic foot ulcers, venous leg ulcers, pressure ulcers, burns, and other wounds that do not progress past the inflammatory stage of healing. The amniotic membrane is a semi-permeable protective barrier that supports the healing cascade.


Currently, amniotic membrane is experiencing widespread use in the area of ophthalmic surgery (eye surgery) as a substrate (foundation) to replace the damaged ocular tissue, as a patch (biological graft), or as a combination of both. Doctors use it to treat chemical burns, corneal ulceration, Stevens-Johnson Syndrome, and pterygium excision. MiMedx's amnion-based products have been successfully used as a reconstructive aid in over 50,000 ophthalmic surgeries.


Amniotic membrane is currently showing great promise in the area of dentistry to treat gum disease. Without the use of amnion, the patient is forced to have tissue harvested from his/her soft palate to replace the lost gum tissue.


Soft tissue injuries are common in sports and occur as a result of trauma or overuse. Small tears in the tissue become inflamed and if chronic, may weaken and be more prone to tear. The amniotic membrane is a treatment option for these types of injuries. It is a semi-permeable protective barrier that supports the healing cascade.


MiMedx is committed to the safety of its products and the patients who receive them. Donor screening and serological testing is performed for each donation according to strict guidelines set forth by both the United States Food and Drug Administration (FDA) and the American Association of Tissue Banks (AATB) to eliminate any donation that poses a risk of infectious disease transmission.

Once donor screening and serological testing is complete, the donated tissue is processed using MiMedx's patented Purion® Process. The product undergoes active preservation of the extracellular matrix (ECM), regulatory proteins, and removal of blood contaminants via a proprietary cleansing process. For an additional level of safety, the product is terminally sterilized.